Structural biology: Variability without change

Structural biology

doesn't know which Academy member is handling the paper unless it is accepted. To make room for the extra papers to be submitted via track II, PNAS has reduced the number of papers a member is allowed to communicate to the journal annually from six to four. Does the new system work? Those who have tried it say that there are many frustrating teething problems. Apparently one problem is that the...

Global Change Biology

Wetlands evapotranspire more water than other ecosystems, including agricultural, forest and grassland ecosystems. However, the effects of elevated atmospheric carbon dioxide (C02) concentration (Ca) on wetland evapotranspiration (ET) are largely unknown. Here, we present data on 12 years of measurements of ET, net ecosystem C02 exchange (NEE), and ecosystem water use efficiency (EWUE, i.e. NEE...

The Biology of Change

In this introductory chapter I discuss a number of background issues for developmental cognitive neuroscience, beginning with historical approaches to the nature– nurture debate. Constructivism, in which biological forms are an emergent product of complex dynamic interactions between genes and environment, is presented as an approach to development that is superior to accounts that seek to iden...

Structural biology and cancer

The techniques of structural biology currently play an important role in the development of novel therapeutic agents including cancer chemotherapies. X-ray crystallography has proved to be a particularly powerful tool for both the discovery of novel compounds and their subsequent development. In this review of the literature, the steps involved in the determination of a crystal structure will b...

Structural Biology of Glycoproteins